PrEP is safe. Before Truvada and Descovy were tested and approved for PrEP, they were used to treat people living with HIV. Its safety has been documented and continues to be carefully monitored. However, people with significant kidney disease should not take PrEP. Your prescriber will check your kidneys and monitor you to make sure PrEP is safe for you and, once you start it, that it isn’t causing any problems.
Stomach upset and headaches are common side effects of taking Truvada. These symptoms are usually mild and go away after your body gets used to the drug. Some rare but serious side effects include a build-up of acid in the blood, liver problems, kidney problems, bone problems, changes in body fat, symptoms of inflammation, and complications if you have hepatitis B.
Common side effects in people taking Descovy for PrEP are diarrhea, nausea, headache, fatigue, and stomach pain. Tell your healthcare provider if you have any side effects that bother you or do not go away. Descovy may also worsen conditions in those with a Hepatitis B (HBV) infection. Your healthcare provider will test you for HBV prior to using Descovy, and discuss a proper medication plan with you.